Signaling of extracellular matrices for tissue regeneration and therapeutics
نویسندگان
چکیده
منابع مشابه
Synthetic extracellular matrices for tissue engineering and regeneration.
The need for replacement tissues or organs requires a tissue supply that cannot be satisfied by the donor supply. The tissue engineering and regeneration field is focused on the development of biological tissue and organ substitutes and may provide functional tissues to restore, maintain, or improve tissue formation. This field is already providing new therapeutic options to bypass the limitati...
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Tissue engineering can be defined as an interdisciplinary field applying the principles of engineering and life sciences towards the development of biological substitutes that restore, maintain, or improve tissue function (Langer & Vacanti, 1993). To accomplish this aim, a balanced combination of cell culture growth with supporting biomaterials is required, as well as the introduction of bioact...
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Cell communication is central to the integration of cell function required for the development and homeostasis of multicellular animals. Proteins are an important currency of cell communication, acting locally (auto-, juxta-, or paracrine) or systemically (endocrine). The fibroblast growth factor (FGF) family contributes to the regulation of virtually all aspects of development and organogenesi...
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Tissue engineering may provide an alternative to organ and tissue transplantation, both of which suffer from a limitation of supply. Cell transplantation using biodegradable synthetic extracellular matrices offers the possibility of creating completely natural new tissues and so replacing lost or malfunctioning organs or tissues. Synthetic extracellular matrices fabricated from biocompatible, b...
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Microscale heterogeneity in the extracellular matrix (ECM) provides spatial information that allows tissues to develop and function properly in vivo. This heterogeneity in composition (chemistry) and structure (geometry) creates distinct microenvironments for the cells that comprise a tissue. In response, populations of cells can coordinate their behaviors across micrometer-to-millimeter length...
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ژورنال
عنوان ژورنال: Tissue Engineering and Regenerative Medicine
سال: 2016
ISSN: 1738-2696,2212-5469
DOI: 10.1007/s13770-016-9075-0